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Using oculomotor features to predict changes in optic nerve sheath diameter and ImPACT scores from contact-sport athletes

March 4, 2021
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Journal Article
Author:
Hrishikesh Mohan Rao
…
Published in:
Front. Neurol., 4 March 2021, Art. No. 584684.
Topic:
health
R&D area:
R&D group:

Summary

There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports.
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Summary

There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential...

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Using oculomotor features to predict changes in optic nerve sheath diameter and ImPACT scores from contact-sport athletes

Beamforming with distributed arrays: FY19 RF Systems Line-Supported Program

January 7, 2020
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Project Report
Author:
Keith W. Forsythe
…
Published in:
MIT Lincoln Laboratory Report LSP-270
Topic:
antennas
R&D area:
R&D group:

Summary

Spatial beamforming using distributed arrays of RF sensors is treated. Unlike the observations from traditional RF antenna arrays, the distributed array's data can be subjected to widely varying time and frequency shifts among sensors and signals. These shifts require compensation upon reception in order to perform spatial filtering. To perform beamforming with a distributed array, the complex-valued observations from the sensors are shifted in time and frequency, weighted, and summed to form a beamformer output that is designed to mitigate interference and enhance signal energy. The appropriate time-frequency shifts required for good beamforming are studied here using several different methodologies.
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Summary

Spatial beamforming using distributed arrays of RF sensors is treated. Unlike the observations from traditional RF antenna arrays, the distributed array's data can be subjected to widely varying time and frequency shifts among sensors and signals. These shifts require compensation upon reception in order to perform spatial filtering. To perform...

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Beamforming with distributed arrays: FY19 RF Systems Line-Supported Program

Collaborative and passive channel gain estimation in fading environments

June 12, 2019
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Journal Article
Author:
Binoy G. Kurien
Published in:
IEEE Trans. Cognitive Commun. and Netw., Vol. 5, No. 4, December 2019, pp. 863-72.
Topic:
communications
R&D area:
R&D group:

Summary

Dynamic spectrum access techniques are typically aided by knowledge of the wireless channel gains among participating radios, as this knowledge allows the potential interference impact of any radio's transmissions on its neighbors to be quantified. We present a technique for collaborative inference of the channel gains which relies solely on the radios monitoring their aggregate transmitted and received energies as they transmit their data packets. We demonstrate that through low data-rate exchange of these energy metrics among bursty networks, the gains can be jointly estimated within a dB and with low latency on the order of seconds. In particular, we derive the best linear unbiased estimator (BLUE) for the gains. While this estimator relies on knowledge of fading parameters not known in practice, we propose a practical variant which achieves performance comparable to the BLUE in the realistic fading setting used in our simulations.
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Summary

Dynamic spectrum access techniques are typically aided by knowledge of the wireless channel gains among participating radios, as this knowledge allows the potential interference impact of any radio's transmissions on its neighbors to be quantified. We present a technique for collaborative inference of the channel gains which relies solely on...

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Collaborative and passive channel gain estimation in fading environments

Detecting pathogen exposure during the non-symptomatic incubation period using physiological data

November 13, 2017
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Journal Article
Author:
Lauren Milechin
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Published in:
bioRxiv preprint doi: https://doi.org/10.1101/218818, 13 November 2017.
Topic:
biomedical
R&D area:
R&D group:

Summary

Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states during the incubation period using subtle, sub-clinical physiological markers. Starting with highresolution physiological waveform data from non-human primate studies of viral (Ebola, Marburg, Lassa, and Nipah viruses) and bacterial (Y. pestis) exposure, we processed the data to reduce short-term variability and normalize diurnal variations, then provided these to a supervised random forest classification algorithm and post-classifier declaration logic step to reduce false alarms. In most subjects detection is achieved well before the onset of fever; subject cross-validation across exposure studies (varying viruses, exposure routes, animal species, and target dose) lead to 51h mean early detection (at 0.93 area under the receiver-operating characteristic curve [AUCROC]). Evaluating the algorithm against entirely independent datasets for Lassa, Nipah, and Y. pestis exposures un-used in algorithm training and development yields a mean 51h early warning time (at AUCROC=0.95). We discuss which physiological indicators are most informative for early detection and options for extending this capability to limited datasets such as those available from wearable, non-invasive, ECG-based sensors.
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Summary

Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states...

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Detecting pathogen exposure during the non-symptomatic incubation period using physiological data

Detecting virus exposure during the pre-symptomatic incubation period using physiological data

March 3, 2017
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Journal Article
Author:
Lauren Milechin
…
Published in:
Science Translational Medicine (submitted), 3 March 2017.
Topic:
detection systems
R&D area:
R&D group:

Summary

Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning method to better detect asymptomatic states during the incubation period using subtle, sub-clinical physiological markers. Using high-resolution physiological data from non-human primate studies of Ebola and Marburg viruses, we pre-processed the data to reduce short-term variability and normalize diurnal variations, then provided these to a supervised random forest classification algorithm. In most subjects detection is achieved well before the onset of fever; subject cross-validation lead to 52±14h mean early detection (at >0.90 area under the receiver-operating characteristic curve). Cross-cohort tests across pathogens and exposure routes also lead to successful early detection (28±16h and 43±22h, respectively). We discuss which physiological indicators are most informative for early detection and options for extending this capability to lower data resolution and wearable, non-invasive sensors.
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Summary

Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning method to better detect asymptomatic states during...

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Detecting virus exposure during the pre-symptomatic incubation period using physiological data

Distributed multi-modal sensor system for searching a foliage-covered region

April 28, 2011
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Conference Paper
Author:
Matthew R Fetterman
…
Published in:
2011 IEEE Conf. on Technologies for Practical Robot Applications (TePRA), 28 April 2011, pp. 7-14.
Topic:
sensors
R&D area:
R&D group:

Summary

We designed and constructed a system that includes aircraft, ground vehicles, and throwable sensors to search a semiforested region that was partially covered by foliage. The system contained 4 radio-controlled (RC) trucks, 2 aircraft, and 30 SensorMotes (throwable sensors). We also investigated communications links, search strategies, and system architecture. Our system is designed to be low-cost, contain a variety of sensors, and distributed so that the system is robust even if individual components are lost.
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Summary

We designed and constructed a system that includes aircraft, ground vehicles, and throwable sensors to search a semiforested region that was partially covered by foliage. The system contained 4 radio-controlled (RC) trucks, 2 aircraft, and 30 SensorMotes (throwable sensors). We also investigated communications links, search strategies, and system architecture. Our...

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Distributed multi-modal sensor system for searching a foliage-covered region

Circuit-fed tile-approach configuration for millimeter-wave spatial power combining

January 1, 2002
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Journal Article
Author:
Mark A. Gouker
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Published in:
IEEE Trans. Microw. Theory Tech., Vol. 50, No. 1, Part 1, January 2002, pp. 17-21.
Topic:
antennas
R&D area:
R&D group:

Summary

In this paper, a circuit-fed spatially combined transmitter array is described for operation at 44 GHz. The array contains 256 elements where each element consists of a monolithic-microwave integrated-circuit amplifier and a circularly polarized microchip patch antenna. The array is constructed using 16-element tile-approach subarrays. Each subarray is a two RF-level (three-dimensional) multichip module containing integrated microstrip patch antennas. The basic construction of the transmitter array resembles tile-approach phased arrays; however, the implementation has been tailored for the power-combining application. The peak performance at 43.5 GHz is equivalent isotropic radiated power of 40.6 dBW (11570 W), effective transmitted power (Peff) of 5.9 W, dc-to-RF efficiency of 7.3%, and system gain of 35 dB.
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Summary

In this paper, a circuit-fed spatially combined transmitter array is described for operation at 44 GHz. The array contains 256 elements where each element consists of a monolithic-microwave integrated-circuit amplifier and a circularly polarized microchip patch antenna. The array is constructed using 16-element tile-approach subarrays. Each subarray is a two...

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Circuit-fed tile-approach configuration for millimeter-wave spatial power combining

Comparison of two flat reflector-type designs for dual-polarization, dual-band operation

July 8, 2001
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Conference Paper
Author:
Sean M. Duffy
…
Published in:
IEEE Antennas and Propagation Society Int. Synp. 2001 Digest, Vol. 2, 8-13 July 2001, pp. 288-291.
Topic:
antennas
R&D area:
R&D group:

Summary

The parabolic reflector remains an essential antenna for high-gain applications. This is a result of its desirable characteristics based on geometric optics. These include relative frequency independence for sufficiently large apertures and high aperture efficiency. However, the parabolic reflector occupies a large volume. This may be aesthetically unappealing on the sides of buildings and structures. Also, from a mobile user perspective, a desirable characteristic is having a large aperture during operation while having a small volume when packed away and not in use. The parabolic reflector is typically constructed of multiple petals for mobile uses, but it does not pack into as small a volume as a flat, thin antenna would due to the curvature of the paraboloid. Therefore, the primary goal of the antennas studied in this work is developing flat reflector antennas to utilize the advantages of large reflector apertures while remaining capable of packing into a small volume. In addition, system requiremenls dictated dual-band, dual-polarized operation. Two flat reflectors are compared: a reflectarray and a zoned reflector. While each design is inherently narrow-band, methods of achieving dual-band operation were employed.
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Summary

The parabolic reflector remains an essential antenna for high-gain applications. This is a result of its desirable characteristics based on geometric optics. These include relative frequency independence for sufficiently large apertures and high aperture efficiency. However, the parabolic reflector occupies a large volume. This may be aesthetically unappealing on the...

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Comparison of two flat reflector-type designs for dual-polarization, dual-band operation

Accurate modeling of dual dipole and slot elements used with photomixers for coherent terahertz output power

June 1, 2001
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Journal Article
Author:
Sean M. Duffy
…
Published in:
IEEE Trans. Microw. Theory Tech., Vol. 49, No. 6, June 2001, pp. 1032-8.
Topic:
antennas
R&D area:
R&D group:

Summary

Accurate circuit models derived from electromagnetic simulations have been used to fabricate photomixer sources with optimized high-impedance antennas. Output powers on the order of 1 uW were measured for various designs spanning 0.6-2.7 THz. The improvement in output power ranged from 3 to 10 dB over more conventionally designed photomixers using broad-band log-spiral antennas. Measured data on single dipoles, twin dipoles, and twin slots are in good agreement with the characteristics predicted by the design simulations.
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Summary

Accurate circuit models derived from electromagnetic simulations have been used to fabricate photomixer sources with optimized high-impedance antennas. Output powers on the order of 1 uW were measured for various designs spanning 0.6-2.7 THz. The improvement in output power ranged from 3 to 10 dB over more conventionally designed photomixers...

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Accurate modeling of dual dipole and slot elements used with photomixers for coherent terahertz output power

MEMS microswitches for reconfigurable microwave circuitry

March 1, 2001
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Journal Article
Author:
Sean M. Duffy
…
Published in:
IEEE Microw. Wirel. Compon. Lett., Vol. 11, No. 3, March 2001, pp. 106-108.
Topic:
antennas
R&D area:
R&D group:

Summary

The performance is reported for a new microelectromechanical structure (MEMS) cantilever microswitch. We report on both dc- and capacitively-contacted microswitches. The dc-contacted microswitches have contact resistance of less than 1 ohm, and the RF loss of the switch up to 40 GHz in the closed position is 0.1-0.2 dB. Capacitively-contacted switches have an impedance ratio of 141:1 from the open to closed state and in the closed position have a series capacitance of 1.2 pF. The capacitively-contacted switches have been measured up to 40 GHz with S(21) less than -0.7 dB across the 5-40 GHz band.
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Summary

The performance is reported for a new microelectromechanical structure (MEMS) cantilever microswitch. We report on both dc- and capacitively-contacted microswitches. The dc-contacted microswitches have contact resistance of less than 1 ohm, and the RF loss of the switch up to 40 GHz in the closed position is 0.1-0.2 dB. Capacitively-contacted...

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MEMS microswitches for reconfigurable microwave circuitry
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