Publications
Kawasaki disease, multisystem inflammatory syndrome in children: antibody-induced mast cell activation hypothesis
Summary
Summary
Multisystem Inflammatory Syndrome in Children (MIS-C) is appearing in infants, children, and young adults in association with COVID-19 (coronavirus disease 2019) infections of SARS-CoV-2. Kawasaki Disease (KD) is one of the most common vasculitides of childhood. KD presents with similar symptoms to MIS-C especially in severe forms such as Kawasaki...
Medical countermeasures analysis of 2019-nCoV and vaccine risks for antibody-dependent enhancement (ADE)
Summary
Summary
Background: In 80% of patients, COVID-19 presents as mild disease. 20% of cases develop severe (13%) or critical (6%) illness. More severe forms of COVID-19 present as clinical severe acute respiratory syndrome, but include a T-predominant lymphopenia, high circulating levels of proinflammatory cytokines and chemokines, accumulation of neutrophils and macrophages...
Comparison of two-talker attention decoding from EEG with nonlinear neural networks and linear methods
Summary
Summary
Auditory attention decoding (AAD) through a brain-computer interface has had a flowering of developments since it was first introduced by Mesgarani and Chang (2012) using electrocorticograph recordings. AAD has been pursued for its potential application to hearing-aid design in which an attention-guided algorithm selects, from multiple competing acoustic sources, which...
The Human Trafficking Technology Roadmap: a targeted development strategy for the Department of Homeland Security
Summary
Summary
Human trafficking is a form of modern-day slavery that involves the use of force, fraud, or coercion for the purposes of involuntary labor and sexual exploitation. It affects tens of million of victims worldwide and generates tens of billions of dollars in illicit profits annually. While agencies across the U.S...
Detection and characterization of human trafficking networks using unsupervised scalable text template matching
Summary
Summary
Human trafficking is a form of modern-day slavery affecting an estimated 40 million victims worldwide, primarily through the commercial sexual exploitation of women and children. In the last decade, the advertising of victims has moved from the streets to websites on the Internet, providing greater efficiency and anonymity for sex...
Large-scale Bayesian kinship analysis
Summary
Summary
Kinship prediction in forensics is limited to first degree relatives due to the small number of short tandem repeat loci characterized. The Genetic Chain Rule for Probabilistic Kinship Estimation can leverage large panels of single nucleotide polymorphisms (SNPs) or sets of sequence linked SNPs, called haploblocks, to estimate more distant...
Detecting pathogen exposure during the non-symptomatic incubation period using physiological data
Summary
Summary
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states...
Cloud computing in tactical environments
Summary
Summary
Ground personnel at the tactical edge often lack data and analytics that would increase their effectiveness. To address this problem, this work investigates methods to deploy cloud computing capabilities in tactical environments. Our approach is to identify representative applications and to design a system that spans the software/hardware stack to...
A cloud-based brain connectivity analysis tool
Summary
Summary
With advances in high throughput brain imaging at the cellular and sub-cellular level, there is growing demand for platforms that can support high performance, large-scale brain data processing and analysis. In this paper, we present a novel pipeline that combines Accumulo, D4M, geohashing, and parallel programming to manage large-scale neuron...
A linear algebra approach to fast DNA mixture analysis using GPUs
Summary
Summary
Analysis of DNA samples is an important step in forensics, and the speed of analysis can impact investigations. Comparison of DNA sequences is based on the analysis of short tandem repeats (STRs), which are short DNA sequences of 2-5 base pairs. Current forensics approaches use 20 STR loci for analysis...