Rare Earth Spatial/Spectral Microparticle Barcodes for Labeling of Objects and Tissues

The encoding and labeling of articles and tissues is important in various fields such as healthcare, bioinformatics, and scientific research. A precise and unambiguous method is necessary to avoid errors, misdiagnosis, and misinterpretation. However, conventional methods of labeling often lack the specificity and accuracy required for complex scientific applications. Traditional encoding methodologies, such as barcoding or color coding, suffer from common difficulties, including spectral overlap, low resolution, and instability under certain conditions. Their application also often involves time-consuming processes and expensive reagents. As such, there is a significant need for alternative methods that can offer more precise encoding and labeling, preferably leveraging more stable materials and efficient processes.

Technology Description

The developed technology is centered around polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN). These UCNs, possessing spectrally distinguishable emission spectra, are strategically positioned in different portions of the encoding region within each microparticle. This design allows for the precise labeling and identification of various articles and tissues. The uniqueness of this technology lies in its ability to use UCNs for encoding microparticles, making it possible to create labels with distinct spectral patterns. This spectral differentiation offers a higher level of detail and specificity, resulting in superior object and tissue labeling accuracy compared to other methods.