The integration of Remotely Piloted Vehicles (RF'Vs) into civil airspace will require new methods of ensuring aircraft separation. This paper discusses issues affecting requirements for RPV traffic avoidance systems and for performing the safety evaluations that will be necessary to certify such systems. The paper outlines current ways in which traffic avoidance is assured depending on the type of airspace and type of traffic that is encountered. Alternative methods for RPVs to perform traffic avoidance are discussed, including the potential use of new see-and-avoid sensors or the Traffic Alert and Collision Avoidance System (TCAS). Finally, the paper outlines an established safety evaluation process that can be adapted to assure regulatory authorities that RPVs meet level of safety requirements.