Reagent assessment for detection of ammonium ion-molecule complexes
December 1, 2013
Journal Article
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Rapid Commun. Mass Spectrom., Vol. 27, 2013, pp. 2797-2806.
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Summary
An MS-based framework was developed to quantitatively assess API ion-molecule reagent chemistries based on ammonium selectivity versus competing ions, and intrinsic ammonium binding strength and complex survivability for detection. Methyl acetoacetate is an attractive ammonium reagent for vapor-phase API techniques given its high vapor pressure, preferential selectivity, and high critical energy for dissociation.