RTCA has been developing Minimum Operational Performance Standards (MOPS) for Detect and Avoid (DAA) and Command and Control (C2) systems as part of Special Committee – 228 (SC-228). The Phase 1 MOPS were published in 2017 and a Phase 2 effort to revise and extend the Phase 1 MOPS is ongoing. In order for the MOPS to be fully utilized, they must be evaluated by the FAA employing the FAA's Safety Risk Management (SRM) process. In order to support the SRM process, there is a need for simulation data focused on the safety of DAA encounters. This analysis focuses on gathering information to validate the use of SC-228 MOPS compliant DAA and C2 systems to enable routine UAS operations in the National Airspace System (NAS) without a chase aircraft or visual observers. The scope of this effort aligns with the SC-228 Terms of Reference (TOR) that can be generally characterized as UAS flying IFR and receiving ATC separation services. This analysis evaluates the system safety in mixed classes B, C, D, E, and G airspaces, and includes IFR, VFR, Cooperative, and Non-Cooperative aircraft. This analysis plan describes the four analysis tasks (Section 2) and the simulation plan (Section 3) that will be executed to accomplish these tasks. It is expected that this analysis plan will be extended to include the analysis results and become the final deliverable.