Publications
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Large-scale Bayesian kinship analysis
Summary
Summary
Kinship prediction in forensics is limited to first degree relatives due to the small number of short tandem repeat loci characterized. The Genetic Chain Rule for Probabilistic Kinship Estimation can leverage large panels of single nucleotide polymorphisms (SNPs) or sets of sequence linked SNPs, called haploblocks, to estimate more distant...
Lessons learned from a decade of providing interactive, on-demand high performance computing to scientists and engineers
Summary
Summary
For decades, the use of HPC systems was limited to those in the physical sciences who had mastered their domain in conjunction with a deep understanding of HPC architectures and algorithms. During these same decades, consumer computing device advances produced tablets and smartphones that allow millions of children to interactively...
Performance measurements of supercomputing and cloud storage solutions
Summary
Summary
Increasing amounts of data from varied sources, particularly in the fields of machine learning and graph analytics, are causing storage requirements to grow rapidly. A variety of technologies exist for storing and sharing these data, ranging from parallel file systems used by supercomputers to distributed block storage systems found in...
A cloud-based brain connectivity analysis tool
Summary
Summary
With advances in high throughput brain imaging at the cellular and sub-cellular level, there is growing demand for platforms that can support high performance, large-scale brain data processing and analysis. In this paper, we present a novel pipeline that combines Accumulo, D4M, geohashing, and parallel programming to manage large-scale neuron...
Learning by doing, High Performance Computing education in the MOOC era
Summary
Summary
The High Performance Computing (HPC) community has spent decades developing tools that teach practitioners to harness the power of parallel and distributed computing. To create scalable and flexible educational experiences for practitioners in all phases of a career, we turn to Massively Open Online Courses (MOOCs). We detail the design...
Benchmarking the Graphulo processing framework
Summary
Summary
Graph algorithms have wide applicability to a variety of domains and are often used on massive datasets. Recent standardization efforts such as the GraphBLAS are designed to specify a set of key computational kernels that hardware and software developers can adhere to. Graphulo is a processing framework that enables GraphBLAS...
Enhancing HPC security with a user-based firewall
Summary
Summary
High Performance Computing (HPC) systems traditionally allow their users unrestricted use of their internal network. While this network is normally controlled enough to guarantee privacy without the need for encryption, it does not provide a method to authenticate peer connections. Protocols built upon this internal network, such as those used...
Novel graph processor architecture, prototype system, and results
Summary
Summary
Graph algorithms are increasingly used in applications that exploit large databases. However, conventional processor architectures are inadequate for handling the throughput and memory requirements of graph computation. Lincoln Laboratory's graph-processor architecture represents a rethinking of parallel architectures for graph problems. Our processor utilizes innovations that include a sparse matrix-based graph...
Benchmarking SciDB data import on HPC systems
Summary
Summary
SciDB is a scalable, computational database management system that uses an array model for data storage. The array data model of SciDB makes it ideally suited for storing and managing large amounts of imaging data. SciDB is designed to support advanced analytics in database, thus reducing the need for extracting...
From NoSQL Accumulo to NewSQL Graphulo: design and utility of graph algorithms inside a BigTable database
Summary
Summary
Google BigTable's scale-out design for distributed key-value storage inspired a generation of NoSQL databases. Recently the NewSQL paradigm emerged in response to analytic workloads that demand distributed computation local to data storage. Many such analytics take the form of graph algorithms, a trend that motivated the GraphBLAS initiative to standardize...