Publications
Detecting pathogen exposure during the non-symptomatic incubation period using physiological data: proof of concept in non-human primates
September 3, 2021
Journal Article
Published in:
Front Physiol., Vol. 12, September 2021, Article 691074.
Summary
Background and Objectives: Early warning of bacterial and viral infection, prior to the development of overt clinical symptoms, allows not only for improved patient care and outcomes but also enables faster implementation of public health measures (patient isolation and contact tracing). Our primary objectives in this effort are 3-fold. First, we seek to determine the upper limits of early warning detection through physiological measurements. Second, we investigate whether the detected physiological response is specific to the pathogen. Third, we explore the feasibility of extending early warning detection with wearable devices. Research Methods: For the first objective, we developed a supervised random forest algorithm to detect pathogen exposure in the asymptomatic period prior to overt symptoms (fever). We used high-resolution physiological telemetry data (aortic blood pressure, intrathoracic pressure, electrocardiograms, and core temperature) from non-human primate animal models exposed to two viral pathogens: Ebola and Marburg (N = 20). Second, to determine reusability across different pathogens, we evaluated our algorithm against three independent physiological datasets from non-human primate models (N = 13) exposed to three different pathogens: Lassa and Nipah viruses and Y. pestis. For the third objective, we evaluated performance degradation when the algorithm was restricted to features derived from electrocardiogram (ECG) waveforms to emulate data from a non-invasive wearable device. Results: First, our cross-validated random forest classifier provides a mean early warning of 51 ± 12 h, with an area under the receiver-operating characteristic curve (AUC) of 0.93 ± 0.01. Second, our algorithm achieved comparable performance when applied to datasets from different pathogen exposures – a mean early warning of 51 ± 14 h and AUC of 0.95 ± 0.01. Last, with a degraded feature set derived solely from ECG, we observed minimal degradation – a mean early warning of 46 ± 14 h and AUC of 0.91 ± 0.001. Conclusion: Under controlled experimental conditions, physiological measurements can provide over 2 days of early warning with high AUC. Deviations in physiological signals following exposure to a pathogen are due to the underlying host’s immunological response and are not specific to the pathogen. Pre-symptomatic detection is strong even when features are limited to ECG-derivatives, suggesting that this approach may translate to non-invasive wearable devices.
Summary
Background and Objectives: Early warning of bacterial and viral infection, prior to the development of overt clinical symptoms, allows not only for improved patient care and outcomes but also enables faster implementation of public health measures (patient isolation and contact tracing). Our primary objectives in this effort are 3-fold. First...
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GraphChallenge.org triangle counting performance [e-print]
September 22, 2020
Conference Paper
Published in:
2020 IEEE High Performance Computing Conf., HPEC, 22-24 September 2020.
Summary
The rise of graph analytic systems has created a need for new ways to measure and compare the capabilities of graph processing systems. The MIT/Amazon/IEEE Graph Challenge has been developed to provide a well-defined community venue for stimulating research and highlighting innovations in graph analysis software, hardware, algorithms, and systems. GraphChallenge.org provides a wide range of preparsed graph data sets, graph generators, mathematically defined graph algorithms, example serial implementations in a variety of languages, and specific metrics for measuring performance. The triangle counting component of GraphChallenge.org tests the performance of graph processing systems to count all the triangles in a graph and exercises key graph operations found in many graph algorithms. In 2017, 2018, and 2019 many triangle counting submissions were received from a wide range of authors and organizations. This paper presents a performance analysis of the best performers of these submissions. These submissions show that their state-of-the-art triangle counting execution time, Ttri, is a strong function of the number of edges in the graph, Ne, which improved significantly from 2017 (Ttri \approx (Ne/10^8)^4=3) to 2018 (Ttri \approx Ne/10^9) and remained comparable from 2018 to 2019. Graph Challenge provides a clear picture of current graph analysis systems and underscores the need for new innovations to achieve high performance on very large graphs
Summary
The rise of graph analytic systems has created a need for new ways to measure and compare the capabilities of graph processing systems. The MIT/Amazon/IEEE Graph Challenge has been developed to provide a well-defined community venue for stimulating research and highlighting innovations in graph analysis software, hardware, algorithms, and systems...
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GraphChallenge.org sparse deep neural network performance [e-print]
September 22, 2020
Conference Paper
Published in:
2020 IEEE High Performance Computing Conf., HPEC, 22-24 September 2020.
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Summary
The MIT/IEEE/Amazon GraphChallenge.org encourages community approaches to developing new solutions for analyzing graphs and sparse data. Sparse AI analytics present unique scalability difficulties. The Sparse Deep Neural Network (DNN) Challenge draws upon prior challenges from machine learning, high performance computing, and visual analytics to create a challenge that is reflective of emerging sparse AI systems. The sparse DNN challenge is based on a mathematically well-defined DNN inference computation and can be implemented in any programming environment. In 2019 several sparse DNN challenge submissions were received from a wide range of authors and organizations. This paper presents a performance analysis of the best performers of these submissions. These submissions show that their state-of-the-art sparse DNN execution time, TDNN, is a strong function of the number of DNN operations performed, Nop. The sparse DNN challenge provides a clear picture of current sparse DNN systems and underscores the need for new innovations to achieve high performance on very large sparse DNNs.
Summary
The MIT/IEEE/Amazon GraphChallenge.org encourages community approaches to developing new solutions for analyzing graphs and sparse data. Sparse AI analytics present unique scalability difficulties. The Sparse Deep Neural Network (DNN) Challenge draws upon prior challenges from machine learning, high performance computing, and visual analytics to create a challenge that is reflective...
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75,000,000,000 streaming inserts/second using hierarchical hypersparse GraphBLAS matrices
May 18, 2020
Conference Paper
Published in:
2020 IEEE Intl. Parallel and Distributed Processing Symp. Workshops, IPDPSW, 18-22 May 2020.
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Summary
The SuiteSparse GraphBLAS C-library implements high performance hypersparse matrices with bindings to a variety of languages (Python, Julia, and Matlab/Octave). GraphBLAS provides a lightweight in-memory database implementation of hypersparse matrices that are ideal for analyzing many types of network data, while providing rigorous mathematical guarantees, such as linearity. Streaming updates of hypersparse matrices put enormous pressure on the memory hierarchy. This work benchmarks an implementation of hierarchical hypersparse matrices that reduces memory pressure and dramatically increases the update rate into a hypersparse matrices. The parameters of hierarchical hypersparse matrices rely on controlling the number of entries in each level in the hierarchy before an update is cascaded. The parameters are easily tunable to achieve optimal performance for a variety of applications. Hierarchical hypersparse matrices achieve over 1,000,000 updates per second in a single instance. Scaling to 31,000 instances of hierarchical hypersparse matrices arrays on 1,100 server nodes on the MIT SuperCloud achieved a sustained update rate of 75,000,000,000 updates per second. This capability allows the MIT SuperCloud to analyze extremely large streaming network data sets.
Summary
The SuiteSparse GraphBLAS C-library implements high performance hypersparse matrices with bindings to a variety of languages (Python, Julia, and Matlab/Octave). GraphBLAS provides a lightweight in-memory database implementation of hypersparse matrices that are ideal for analyzing many types of network data, while providing rigorous mathematical guarantees, such as linearity. Streaming updates...
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Cultivating professional technical skills and understanding through hands-on online learning experiences
October 23, 2019
Conference Paper
Published in:
2019 IEEE Learning with MOOCS, LWMOOCS, 23-25 October 2019.
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Summary
Life-long learning is necessary for all professions because the technologies, tools and skills required for success over the course of a career expand and change. Professionals in science, technology, engineering and mathematics (STEM) fields face particular challenges as new multi-disciplinary methods, e.g. Machine Learning and Artificial Intelligence, mature to replace those learned in undergraduate or graduate programs. Traditionally, industry, professional societies and university programs have provided professional development. While these provide opportunities to develop deeper understanding in STEM specialties and stay current with new techniques, the constraints on formal classes and workshops preclude the possibility of Just-In-Time Mastery Learning, particularly for new domains. The MIT Lincoln Laboratory Supercomputing Center (LLSC) and MIT Supercloud teams have developed online course offerings specifically designed to provide a way for adult learners to build their own educational path based on their immediate needs, problems and schedules. To satisfy adult learners, the courses are formulated as a series of challenges and strategies. Using this perspective, the courses incorporate targeted theory supported by hands-on practice. The focus of this paper is the design of Mastery, Just-in-Time MOOC courses that address the full space of hands-on learning requirements, from digital to analog. The discussion centers on the design of project-based exercises for professional technical education courses. The case studies highlight examples from courses that incorporate practice ranging from the construction of a small radar used for real world data collection and processing to the development of high performance computing applications.
Summary
Life-long learning is necessary for all professions because the technologies, tools and skills required for success over the course of a career expand and change. Professionals in science, technology, engineering and mathematics (STEM) fields face particular challenges as new multi-disciplinary methods, e.g. Machine Learning and Artificial Intelligence, mature to replace...
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Large scale parallelization using file-based communications
September 24, 2019
Conference Paper
Published in:
2019 IEEE High Performance Computing Conf., HPEC, 24-26 September 2019.
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In this paper, we present a novel and new file-based communication architecture using the local filesystem for large scale parallelization. This new approach eliminates the issues with filesystem overload and resource contention when using the central filesystem for large parallel jobs. The new approach incurs additional overhead due to inter-node message file transfers when both the sending and receiving processes are not on the same node. However, even with this additional overhead cost, its benefits are far greater for the overall cluster operation in addition to the performance enhancement in message communications for large scale parallel jobs. For example, when running a 2048-process parallel job, it achieved about 34 times better performance with MPI_Bcast() when using the local filesystem. Furthermore, since the security for transferring message files is handled entirely by using the secure copy protocol (scp) and the file system permissions, no additional security measures or ports are required other than those that are typically required on an HPC system.
Summary
In this paper, we present a novel and new file-based communication architecture using the local filesystem for large scale parallelization. This new approach eliminates the issues with filesystem overload and resource contention when using the central filesystem for large parallel jobs. The new approach incurs additional overhead due to inter-node...
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Survey and benchmarking of machine learning accelerators
September 24, 2019
Conference Paper
Published in:
IEEE High Performance Extreme Computing Conf., HPEC, 24-26 September 2019.
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Summary
Advances in multicore processors and accelerators have opened the flood gates to greater exploration and application of machine learning techniques to a variety of applications. These advances, along with breakdowns of several trends including Moore's Law, have prompted an explosion of processors and accelerators that promise even greater computational and machine learning capabilities. These processors and accelerators are coming in many forms, from CPUs and GPUs to ASICs, FPGAs, and dataflow accelerators. This paper surveys the current state of these processors and accelerators that have been publicly announced with performance and power consumption numbers. The performance and power values are plotted on a scatter graph and a number of dimensions and observations from the trends on this plot are discussed and analyzed. For instance, there are interesting trends in the plot regarding power consumption, numerical precision, and inference versus training. We then select and benchmark two commercially-available low size, weight, and power (SWaP) accelerators as these processors are the most interesting for embedded and mobile machine learning inference applications that are most applicable to the DoD and other SWaP constrained users. We determine how they actually perform with real-world images and neural network models, compare those results to the reported performance and power consumption values and evaluate them against an Intel CPU that is used in some embedded applications.
Summary
Advances in multicore processors and accelerators have opened the flood gates to greater exploration and application of machine learning techniques to a variety of applications. These advances, along with breakdowns of several trends including Moore's Law, have prompted an explosion of processors and accelerators that promise even greater computational and...
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Streaming 1.9 billion hyperspace network updates per second with D4M
September 24, 2019
Conference Paper
Published in:
2019 IEEE High Performance Computing Conf., HPEC, 24-26 September 2019.
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Summary
The Dynamic Distributed Dimensional Data Model (D4M) library implements associative arrays in a variety of languages (Python, Julia, and Matlab/Octave) and provides a lightweight in-memory database implementation of hypersparse arrays that are ideal for analyzing many types of network data. D4M relies on associative arrays which combine properties of spreadsheets, databases, matrices, graphs, and networks, while providing rigorous mathematical guarantees, such as linearity. Streaming updates of D4M associative arrays put enormous pressure on the memory hierarchy. This work describes the design and performance optimization of an implementation of hierarchical associative arrays that reduces memory pressure and dramatically increases the update rate into an associative array. The parameters of hierarchical associative arrays rely on controlling the number of entries in each level in the hierarchy before an update is cascaded. The parameters are easily tunable to achieve optimal performance for a variety of applications. Hierarchical arrays achieve over 40,000 updates per second in a single instance. Scaling to 34,000 instances of hierarchical D4M associative arrays on 1,100 server nodes on the MIT SuperCloud achieved a sustained update rate of 1,900,000,000 updates per second. This capability allows the MIT SuperCloud to analyze extremely large streaming network data sets.
Summary
The Dynamic Distributed Dimensional Data Model (D4M) library implements associative arrays in a variety of languages (Python, Julia, and Matlab/Octave) and provides a lightweight in-memory database implementation of hypersparse arrays that are ideal for analyzing many types of network data. D4M relies on associative arrays which combine properties of spreadsheets...
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AI enabling technologies: a survey
May 8, 2019
Journal Article
Published in:
https://arxiv.org/abs/1905.03592
Summary
Artificial Intelligence (AI) has the opportunity to revolutionize the way the United States Department of Defense (DoD) and Intelligence Community (IC) address the challenges of evolving threats, data deluge, and rapid courses of action. Developing an end-to-end artificial intelligence system involves parallel development of different pieces that must work together in order to provide capabilities that can be used by decision makers, warfighters and analysts. These pieces include data collection, data conditioning, algorithms, computing, robust artificial intelligence, and human-machine teaming. While much of the popular press today surrounds advances in algorithms and computing, most modern AI systems leverage advances across numerous different fields. Further, while certain components may not be as visible to end-users as others, our experience has shown that each of these interrelated components play a major role in the success or failure of an AI system. This article is meant to highlight many of these technologies that are involved in an end-to-end AI system. The goal of this article is to provide readers with an overview of terminology, technical details and recent highlights from academia, industry and government. Where possible, we indicate relevant resources that can be used for further reading and understanding.
Summary
Artificial Intelligence (AI) has the opportunity to revolutionize the way the United States Department of Defense (DoD) and Intelligence Community (IC) address the challenges of evolving threats, data deluge, and rapid courses of action. Developing an end-to-end artificial intelligence system involves parallel development of different pieces that must work together...
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A billion updates per second using 30,000 hierarchical in-memory D4M databases
January 24, 2019
Conference Paper
Published in:
North East Database Day, NEDB Day, 24 January 2019.
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Summary
Analyzing large scale networks requires high performance streaming updates of graph representations of these data. Associative arrays are mathematical objects combining properties of spreadsheets, databases, matrices, and graphs, and are well-suited for representing and analyzing streaming network data. The Dynamic Distributed Dimensional Data Model (D4M) library implements associative arrays in a variety of languages (Python, Julia, and Matlab/Octave) and provides a lightweight in-memory database. Associative arrays are designed for block updates. Streaming updates to a large associative array requires a hierarchical implementation to optimize the performance of the memory hierarchy. Running 34,000 instances of a hierarchical D4M associative arrays on 1,100 server nodes on the MIT SuperCloud achieved a sustained update rate of 1,900,000,000 updates per second. This capability allows the MIT SuperCloud to analyze extremely large streaming network data sets.
Summary
Analyzing large scale networks requires high performance streaming updates of graph representations of these data. Associative arrays are mathematical objects combining properties of spreadsheets, databases, matrices, and graphs, and are well-suited for representing and analyzing streaming network data. The Dynamic Distributed Dimensional Data Model (D4M) library implements associative arrays in...
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