Publications
Detecting pathogen exposure during the non-symptomatic incubation period using physiological data: proof of concept in non-human primates
September 3, 2021
Journal Article
Published in:
Front Physiol., Vol. 12, September 2021, Article 691074.
Summary
Background and Objectives: Early warning of bacterial and viral infection, prior to the development of overt clinical symptoms, allows not only for improved patient care and outcomes but also enables faster implementation of public health measures (patient isolation and contact tracing). Our primary objectives in this effort are 3-fold. First, we seek to determine the upper limits of early warning detection through physiological measurements. Second, we investigate whether the detected physiological response is specific to the pathogen. Third, we explore the feasibility of extending early warning detection with wearable devices. Research Methods: For the first objective, we developed a supervised random forest algorithm to detect pathogen exposure in the asymptomatic period prior to overt symptoms (fever). We used high-resolution physiological telemetry data (aortic blood pressure, intrathoracic pressure, electrocardiograms, and core temperature) from non-human primate animal models exposed to two viral pathogens: Ebola and Marburg (N = 20). Second, to determine reusability across different pathogens, we evaluated our algorithm against three independent physiological datasets from non-human primate models (N = 13) exposed to three different pathogens: Lassa and Nipah viruses and Y. pestis. For the third objective, we evaluated performance degradation when the algorithm was restricted to features derived from electrocardiogram (ECG) waveforms to emulate data from a non-invasive wearable device. Results: First, our cross-validated random forest classifier provides a mean early warning of 51 ± 12 h, with an area under the receiver-operating characteristic curve (AUC) of 0.93 ± 0.01. Second, our algorithm achieved comparable performance when applied to datasets from different pathogen exposures – a mean early warning of 51 ± 14 h and AUC of 0.95 ± 0.01. Last, with a degraded feature set derived solely from ECG, we observed minimal degradation – a mean early warning of 46 ± 14 h and AUC of 0.91 ± 0.001. Conclusion: Under controlled experimental conditions, physiological measurements can provide over 2 days of early warning with high AUC. Deviations in physiological signals following exposure to a pathogen are due to the underlying host’s immunological response and are not specific to the pathogen. Pre-symptomatic detection is strong even when features are limited to ECG-derivatives, suggesting that this approach may translate to non-invasive wearable devices.
Summary
Background and Objectives: Early warning of bacterial and viral infection, prior to the development of overt clinical symptoms, allows not only for improved patient care and outcomes but also enables faster implementation of public health measures (patient isolation and contact tracing). Our primary objectives in this effort are 3-fold. First...
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Priority scheduling for multi-function apertures with hard- and soft-time constraints
March 6, 2021
Conference Paper
Published in:
2021 IEEE Aerospace Conf., 6-13 March 2021.
Summary
A multi-function aperture (MFA) is an antenna array that supports multiple RF signals for a diverse set of activities. An MFA may support multiple activities simultaneously if they are compatible, and platforms may utilize multiple MFAs to meet field-of-regard and frequency range requirements. Efficient MFA utilization requires a Resource Manager (RM) that routes signals to the correct MFA based on field-of-view and other requirements, and schedules MFA access to resolve conflicts based on request priority. An efficient RM scheduler time-interleaves requests from different activities as needed. Requested access events may be hard-time—that is, the event must be scheduled at a specified time or not at all, or soft-time, indicating it may be scheduled anytime in a specified window. Hard-time events include communications channels with assigned time slots, and soft-time events include asynchronous communications channels. This paper describes and evaluates an optimal algorithm to jointly schedule sequences of hard-time requests, maximizing the number of scheduled events while meeting priority requirements. An extension of this algorithm provides near-optimal schedules for sequences of soft-time or mixed hard- and soft-time events. Algorithms are evaluated by simulation, using two conflict models. The first is based on fixed signal paths that conflict if two paths share a common resource. The second model assumes the RM dynamically assigns resources. As implemented, these algorithms are too slow for real-time operation, and further work is required. They do provide insight into the MFA management problem, a useful metric for evaluating resource sharing and scheduling approaches, and may suggest efficient sub-optimal algorithms.
Summary
A multi-function aperture (MFA) is an antenna array that supports multiple RF signals for a diverse set of activities. An MFA may support multiple activities simultaneously if they are compatible, and platforms may utilize multiple MFAs to meet field-of-regard and frequency range requirements. Efficient MFA utilization requires a Resource Manager...
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Using oculomotor features to predict changes in optic nerve sheath diameter and ImPACT scores from contact-sport athletes
March 4, 2021
Journal Article
Published in:
Front. Neurol., 4 March 2021, Art. No. 584684.
Topic:
R&D area:
Summary
There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports.
Summary
There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential...
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Beamforming with distributed arrays: FY19 RF Systems Line-Supported Program
January 7, 2020
Project Report
Published in:
MIT Lincoln Laboratory Report LSP-270
Topic:
R&D area:
R&D group:
Summary
Spatial beamforming using distributed arrays of RF sensors is treated. Unlike the observations from traditional RF antenna arrays, the distributed array's data can be subjected to widely varying time and frequency shifts among sensors and signals. These shifts require compensation upon reception in order to perform spatial filtering. To perform beamforming with a distributed array, the complex-valued observations from the sensors are shifted in time and frequency, weighted, and summed to form a beamformer output that is designed to mitigate interference and enhance signal energy. The appropriate time-frequency shifts required for good beamforming are studied here using several different methodologies.
Summary
Spatial beamforming using distributed arrays of RF sensors is treated. Unlike the observations from traditional RF antenna arrays, the distributed array's data can be subjected to widely varying time and frequency shifts among sensors and signals. These shifts require compensation upon reception in order to perform spatial filtering. To perform...
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Collaborative and passive channel gain estimation in fading environments
June 12, 2019
Journal Article
Published in:
IEEE Trans. Cognitive Commun. and Netw., Vol. 5, No. 4, December 2019, pp. 863-72.
Summary
Dynamic spectrum access techniques are typically aided by knowledge of the wireless channel gains among participating radios, as this knowledge allows the potential interference impact of any radio's transmissions on its neighbors to be quantified. We present a technique for collaborative inference of the channel gains which relies solely on the radios monitoring their aggregate transmitted and received energies as they transmit their data packets. We demonstrate that through low data-rate exchange of these energy metrics among bursty networks, the gains can be jointly estimated within a dB and with low latency on the order of seconds. In particular, we derive the best linear unbiased estimator (BLUE) for the gains. While this estimator relies on knowledge of fading parameters not known in practice, we propose a practical variant which achieves performance comparable to the BLUE in the realistic fading setting used in our simulations.
Summary
Dynamic spectrum access techniques are typically aided by knowledge of the wireless channel gains among participating radios, as this knowledge allows the potential interference impact of any radio's transmissions on its neighbors to be quantified. We present a technique for collaborative inference of the channel gains which relies solely on...
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Detecting pathogen exposure during the non-symptomatic incubation period using physiological data
November 13, 2017
Journal Article
Published in:
bioRxiv preprint doi: https://doi.org/10.1101/218818, 13 November 2017.
Summary
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states during the incubation period using subtle, sub-clinical physiological markers. Starting with highresolution physiological waveform data from non-human primate studies of viral (Ebola, Marburg, Lassa, and Nipah viruses) and bacterial (Y. pestis) exposure, we processed the data to reduce short-term variability and normalize diurnal variations, then provided these to a supervised random forest classification algorithm and post-classifier declaration logic step to reduce false alarms. In most subjects detection is achieved well before the onset of fever; subject cross-validation across exposure studies (varying viruses, exposure routes, animal species, and target dose) lead to 51h mean early detection (at 0.93 area under the receiver-operating characteristic curve [AUCROC]). Evaluating the algorithm against entirely independent datasets for Lassa, Nipah, and Y. pestis exposures un-used in algorithm training and development yields a mean 51h early warning time (at AUCROC=0.95). We discuss which physiological indicators are most informative for early detection and options for extending this capability to limited datasets such as those available from wearable, non-invasive, ECG-based sensors.
Summary
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning based method to better detect asymptomatic states...
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Detecting virus exposure during the pre-symptomatic incubation period using physiological data
March 3, 2017
Journal Article
Published in:
Science Translational Medicine (submitted), 3 March 2017.
Summary
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning method to better detect asymptomatic states during the incubation period using subtle, sub-clinical physiological markers. Using high-resolution physiological data from non-human primate studies of Ebola and Marburg viruses, we pre-processed the data to reduce short-term variability and normalize diurnal variations, then provided these to a supervised random forest classification algorithm. In most subjects detection is achieved well before the onset of fever; subject cross-validation lead to 52±14h mean early detection (at >0.90 area under the receiver-operating characteristic curve). Cross-cohort tests across pathogens and exposure routes also lead to successful early detection (28±16h and 43±22h, respectively). We discuss which physiological indicators are most informative for early detection and options for extending this capability to lower data resolution and wearable, non-invasive sensors.
Summary
Early pathogen exposure detection allows better patient care and faster implementation of public health measures (patient isolation, contact tracing). Existing exposure detection most frequently relies on overt clinical symptoms, namely fever, during the infectious prodromal period. We have developed a robust machine learning method to better detect asymptomatic states during...
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Distributed multi-modal sensor system for searching a foliage-covered region
April 28, 2011
Conference Paper
Published in:
2011 IEEE Conf. on Technologies for Practical Robot Applications (TePRA), 28 April 2011, pp. 7-14.
Summary
We designed and constructed a system that includes aircraft, ground vehicles, and throwable sensors to search a semiforested region that was partially covered by foliage. The system contained 4 radio-controlled (RC) trucks, 2 aircraft, and 30 SensorMotes (throwable sensors). We also investigated communications links, search strategies, and system architecture. Our system is designed to be low-cost, contain a variety of sensors, and distributed so that the system is robust even if individual components are lost.
Summary
We designed and constructed a system that includes aircraft, ground vehicles, and throwable sensors to search a semiforested region that was partially covered by foliage. The system contained 4 radio-controlled (RC) trucks, 2 aircraft, and 30 SensorMotes (throwable sensors). We also investigated communications links, search strategies, and system architecture. Our...
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Circuit-fed tile-approach configuration for millimeter-wave spatial power combining
January 1, 2002
Journal Article
Published in:
IEEE Trans. Microw. Theory Tech., Vol. 50, No. 1, Part 1, January 2002, pp. 17-21.
Topic:
Summary
In this paper, a circuit-fed spatially combined transmitter array is described for operation at 44 GHz. The array contains 256 elements where each element consists of a monolithic-microwave integrated-circuit amplifier and a circularly polarized microchip patch antenna. The array is constructed using 16-element tile-approach subarrays. Each subarray is a two RF-level (three-dimensional) multichip module containing integrated microstrip patch antennas. The basic construction of the transmitter array resembles tile-approach phased arrays; however, the implementation has been tailored for the power-combining application. The peak performance at 43.5 GHz is equivalent isotropic radiated power of 40.6 dBW (11570 W), effective transmitted power (Peff) of 5.9 W, dc-to-RF efficiency of 7.3%, and system gain of 35 dB.
Summary
In this paper, a circuit-fed spatially combined transmitter array is described for operation at 44 GHz. The array contains 256 elements where each element consists of a monolithic-microwave integrated-circuit amplifier and a circularly polarized microchip patch antenna. The array is constructed using 16-element tile-approach subarrays. Each subarray is a two...
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Comparison of two flat reflector-type designs for dual-polarization, dual-band operation
July 8, 2001
Conference Paper
Published in:
IEEE Antennas and Propagation Society Int. Synp. 2001 Digest, Vol. 2, 8-13 July 2001, pp. 288-291.
Topic:
Summary
The parabolic reflector remains an essential antenna for high-gain applications. This is a result of its desirable characteristics based on geometric optics. These include relative frequency independence for sufficiently large apertures and high aperture efficiency. However, the parabolic reflector occupies a large volume. This may be aesthetically unappealing on the sides of buildings and structures. Also, from a mobile user perspective, a desirable characteristic is having a large aperture during operation while having a small volume when packed away and not in use. The parabolic reflector is typically constructed of multiple petals for mobile uses, but it does not pack into as small a volume as a flat, thin antenna would due to the curvature of the paraboloid. Therefore, the primary goal of the antennas studied in this work is developing flat reflector antennas to utilize the advantages of large reflector apertures while remaining capable of packing into a small volume. In addition, system requiremenls dictated dual-band, dual-polarized operation. Two flat reflectors are compared: a reflectarray and a zoned reflector. While each design is inherently narrow-band, methods of achieving dual-band operation were employed.
Summary
The parabolic reflector remains an essential antenna for high-gain applications. This is a result of its desirable characteristics based on geometric optics. These include relative frequency independence for sufficiently large apertures and high aperture efficiency. However, the parabolic reflector occupies a large volume. This may be aesthetically unappealing on the...
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